Fármacos

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  IN VITRO SERVICES - Safety    
  Drug Metabolism    
      • Fluorescence based assay
• Human liver microsomes; LC-MS/MS analysis
• Human CYP 450 induction
• Transactivation cell assay
   
         
  Metabolic stability and profiling    
    • Human liver microsomes; LC-MS/MS analysis    
         
Cardiotoxicity    
  Ion channel inhibition: hERG, Nav1.5 and Cav1.2    
    • Fluorescence based assays
• Manual patch clamp assays
   
           
  Neurotoxicity    
    Neurotransmitter receptors    
      Panel of serotonin and dopamine receptors assays:
• 5HT-1A
• 5HT-1B
• 5HT-2A
• 5HT-2C
• hD2