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IN VITRO
SERVICES - Safety
Drug Metabolism
• Fluorescence based assay
• Human liver microsomes; LC-MS/MS analysis
• Human CYP 450 induction
• Transactivation cell assay
Metabolic stability and profiling
• Human liver microsomes; LC-MS/MS analysis
Cardiotoxicity
Ion channel inhibition: hERG, Nav1.5 and Cav1.2
• Fluorescence based assays
• Manual patch clamp assays
Neurotoxicity
Neurotransmitter receptors
Panel of serotonin and dopamine receptors assays:
• 5HT-1A
• 5HT-1B
• 5HT-2A
• 5HT-2C
• hD2
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